Yves Gruel Selected Research

Platelet Factor 4

10/2022	The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodies.
1/2022	Genome-wide association study of platelet factor 4/heparin antibodies in heparin-induced thrombocytopenia.
1/2022	ABO O blood group as a risk factor for platelet reactivity in heparin-induced thrombocytopenia.
3/2021	Characterization of New Monoclonal PF4-Specific Antibodies as Useful Tools for Studies on Typical and Autoimmune Heparin-Induced Thrombocytopenia.
1/2021	COVID-19 patients often show high-titer non-platelet-activating anti-PF4/heparin IgG antibodies.
7/2020	Pathophysiology and Diagnosis of Drug-Induced Immune Thrombocytopenia.
1/2019	Cleavage of anti-PF4/heparin IgG by a bacterial protease and potential benefit in heparin-induced thrombocytopenia.
11/2018	American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.
12/2017	Beneficial effect of exogenous platelet factor 4 for detecting pathogenic heparin-induced thrombocytopenia antibodies.
4/2015	A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record.

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Yves Gruel Research Topics

Disease

42	Thrombocytopenia (Thrombopenia) 10/2022 - 02/2003
18	Thrombosis (Thrombus) 10/2022 - 02/2003
13	Hemorrhage 08/2021 - 08/2002
8	COVID-19 10/2022 - 01/2020
7	Neoplasms (Cancer) 01/2020 - 08/2002
6	Thrombophilia 01/2020 - 06/2006
5	Venous Thromboembolism 10/2021 - 08/2002
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2011 - 01/2007
4	Hemophilia A (Haemophilia) 11/2021 - 10/2009
3	Renal Insufficiency (Renal Failure) 01/2020 - 04/2006
3	Lung Neoplasms (Lung Cancer) 02/2011 - 05/2007
2	Drug-Related Side Effects and Adverse Reactions 01/2022 - 11/2018
2	Critical Illness (Critically Ill) 01/2021 - 01/2021
2	Wounds and Injuries (Trauma) 01/2021 - 01/2020
2	Obesity 01/2020 - 01/2020
2	Thromboembolism 01/2020 - 11/2009
2	Atrial Fibrillation 08/2013 - 06/2013
2	Neoplasm Metastasis (Metastasis) 02/2011 - 01/2009
1	Paraproteinemias (Monoclonal Gammopathy) 01/2022
1	Neuralgia (Stump Neuralgia) 08/2021
1	Intracranial Sinus Thrombosis (Sinus Thrombosis) 01/2021
1	Autoimmune Diseases (Autoimmune Disease) 12/2020
1	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 07/2020
1	Pulmonary Embolism 01/2020
1	Inflammation (Inflammations) 01/2020
1	von Willebrand Diseases (von Willebrand's Disease) 01/2020

Drug/Important Bio-Agent (IBA)

40	Heparin (Liquaemin)FDA LinkGeneric 01/2022 - 02/2003
24	AntibodiesIBA 10/2022 - 02/2003
20	Platelet Factor 4IBA 10/2022 - 02/2003
17	Immunoglobulin G (IgG)IBA 10/2022 - 02/2003
9	AnticoagulantsIBA 01/2022 - 08/2002
5	Factor VIII (Coagulation Factor VIII)IBA 11/2021 - 10/2009
5	Thromboplastin (Tissue Factor)IBA 12/2020 - 07/2003
4	VaccinesIBA 10/2022 - 01/2021
4	Biological ProductsIBA 01/2020 - 06/2003
4	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 01/2020 - 08/2002
4	danaparoid (Orgaran)FDA Link 11/2015 - 04/2006
4	tissue-factor-pathway inhibitor 2 (PP5)IBA 02/2011 - 07/2003
4	lepirudin (Refludan)FDA Link 09/2008 - 04/2006
3	Pharmaceutical PreparationsIBA 07/2020 - 01/2005
3	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 06/2013
3	Fibrinogen (Factor I)FDA Link 01/2020 - 01/2007
3	Dabigatran FDA Link 01/2017 - 06/2013
3	argatroban (MPQA)FDA Link 11/2015 - 06/2006
3	Thrombin FDA Link 06/2013 - 09/2008
2	Intravenous Immunoglobulins (IVIG)FDA Link 12/2021 - 12/2021
2	fibrin fragment D (D-dimer)IBA 10/2021 - 01/2020
2	EnzymesIBA 10/2021 - 12/2017
2	CollagenIBA 08/2021 - 02/2011
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2009
2	AntigensIBA 01/2021 - 01/2021
2	Enoxaparin (Lovenox)FDA LinkGeneric 01/2020 - 08/2002
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 03/2019 - 08/2018
2	TicagrelorIBA 03/2019 - 01/2019
2	RivaroxabanIBA 01/2017 - 06/2013
2	IntegrinsIBA 05/2015 - 02/2011
2	Prothrombin (Factor II)IBA 06/2013 - 07/2005
2	Matrix Metalloproteinases (MMPs)IBA 02/2011 - 01/2009
2	Protein CIBA 10/2010 - 07/2005
2	Messenger RNA (mRNA)IBA 10/2009 - 07/2008
2	AntithrombinsIBA 10/2008 - 07/2005
2	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 05/2007 - 07/2003
2	SodiumIBA 01/2007 - 08/2002
2	ChemokinesIBA 06/2006 - 02/2003
1	FibrinIBA 10/2022
1	estropipate (Ogen)FDA LinkGeneric 10/2022
1	COVID-19 VaccinesIBA 10/2022
1	Blood Group Antigens (Blood Groups)IBA 01/2022
1	simoctocog alfa (Nuwiq)IBA 11/2021
1	Adenosine Diphosphate (ADP)IBA 08/2021
1	Arachidonic Acid (Vitamin F)IBA 08/2021
1	Epinephrine (Adrenaline)FDA LinkGeneric 08/2021
1	Gabapentin (Neurontin)FDA LinkGeneric 08/2021
1	gamma-Aminobutyric Acid (GABA)IBA 08/2021
1	ChAdOx1 nCoV-19IBA 01/2021
1	Monoclonal AntibodiesIBA 01/2021
1	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 07/2020
1	Carbamazepine (Tegretol)FDA LinkGeneric 07/2020
1	Mirtazapine (Rexer)FDA LinkGeneric 07/2020
1	Eptifibatide (Integrilin)FDA Link 07/2020
1	Tirofiban (Aggrastat)FDA Link 07/2020
1	Abciximab (ReoPro)FDA Link 07/2020
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 07/2020
1	Ibuprofen (Motrin)FDA LinkGeneric 07/2020
1	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 07/2020
1	Penicillins (Penicillin)FDA Link 07/2020
1	Quinidine (Chinidin)FDA LinkGeneric 07/2020
1	Quinine (Quinson)FDA Link 07/2020
1	Rifampin (Rifampicin)FDA LinkGeneric 07/2020
1	Suramin (Suramin Sodium)IBA 07/2020
1	Vancomycin FDA LinkGeneric 07/2020
1	von Willebrand FactorIBA 01/2020
1	Oxygen (Dioxygen)IBA 01/2020
1	Oral ContraceptivesIBA 01/2020

Therapy/Procedure

10	Therapeutics 01/2021 - 06/2003
3	Critical Care (Surgical Intensive Care) 01/2021 - 08/2018
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/2021 - 03/2005
2	Stents 01/2019 - 10/2011
1	Extracorporeal Membrane Oxygenation 01/2020
1	Central Venous Catheters 01/2020